High throughput technologies in structural biology

The JCSG high-throughput structural biology pipeline

The Joint Center for Structural Genomics high-throughput structural biology pipeline has delivered more than 1000 structures to the community over the past ten years. The JCSG has made a significant contribution to the overall goal of the NIH Protein Structure Initiative (PSI) of expanding structural coverage of the protein universe, as well as making substantial inroads into structural coverag...

High-throughput sequencing technologies.

The human genome sequence has profoundly altered our understanding of biology, human diversity, and disease. The path from the first draft sequence to our nascent era of personal genomes and genomic medicine has been made possible only because of the extraordinary advancements in DNA sequencing technologies over the past 10 years. Here, we discuss commonly used high-throughput sequencing platfo...

Microfluidic Technologies for Structural Biology

High-throughput biology in the postgenomic era.

HIGH-THROUGHPUT biological methods, namely, methods that perform thousands of simultaneous measurements of biological molecules, have rapidly transformed the landscape of biomedical research during the past decade. Perhaps most central to this transformation has been the sequencing of the human genome and subsequent free release of genomic information, emphasized as a critical goal in the Bermu...

Adipogenic Transcriptome Profiling Using High Throughput Technologies

The recent technological innovations in the area of functional genomics, gene expression/transcriptomic profiling can provide new insights to understand the molecular basis of adipogenesis. The focus of this review is to highlight the recent advances in our understanding of the complex interplay of gene expression events and the regulatory mechanisms of adipogenesis in mouse cell lines, humans ...